Microbicides - What are they?

Page 1 | 2

What are they?

A Microbicide is an anti-infective medication formulated for topical administration before intercourse to protect against HIV and other sexually transmitted infections (STI's).

Why do we need them?

As the vast majority of new HIV infections are by sexual contact, the key to slowing the HIV epidemic is to prevent sexual transmission of HIV.


A vaginal ring – one of the ways in which microbicides could be formulated

Condoms remain the most effective way of stopping sexually transmitted HIV, however, despite widespread efforts to encourage condom use many people do not have the power to avoid sexual contact with partners who may be HIV infected or to ensure condom use. This is particularly the case for women who may not have the ability to control their sexual interactions with men and safeguard their own sexual health. Microbicides have the potential to empower many individuals to protect themselves against HIV.

The fact that microbicides could have a dramatic impact on HIV transmission is indicated by epidemiological modelling performed by the London School of Hygiene and Tropical Medicine. This modelling has indicated that a microbicide that is 60% effective could avoid up to 2.5 million infections worldwide over three years even if it is only used by a moderate number of people (for example if 20% of people who are in contact with local services in 73 low income countries used a microbicide 50% of the time that a condom is not used).